It was revealed in the third volume of Cells at Work! Illegal that the spinoff manga will end with its fourth volume in September.
Like the original manga, the manga is about the cells of the human body working to keep the human body functioning. In Cells at Work! Illegal, the body is of a person who takes illegal substances and is a victim of physical violence.
Kae Hashimoto launched the manga in Kodansha’s YanManga website in January 2022.
Kodansha USA Publishing is also releasing the following spinoff manga in English: Cells at Work: Bacteria!, Cells at Work!: Neo Bacteria!, Cells at Work! White Brigade, Cells at Work! Baby, Cells NOT at Work!, Cells at Work! Code Black, Cells at Work and Friends!, and Cells at Work: Platelets!.
The manga also received an anime adaptation in July 2018. The second season of the anime premiered in January 2021, along with Cells at Work! Code Black spinoff manga.
The series is receiving a live-action adaptation as well.